Maria was born in upper Egypt of a Coptic father and Greek mother and moved to the court of the Muqawqis when she was still very young. She arrived in Medina to join the Prophet's household just after the Prophet returned from the treaty with Quraish which was contracted at al-Hudaybiyya. Maria gave birth to a healthy son in 9 AH, the same year that his daughter Zaynab died, and the Prophet named his new son Ibrahim, after the ancestor of both the Jews and the Christians, the Prophet from whom all the Prophets who came after him were descended. Unfortunately, when he was only eighteen months old, Ibrahim became seriously ill and died. Even though he knew that his small son would go to the Garden, the Prophet Muhammad (peace and blessings of Allah be upon him) could not help shedding some tears. When some of his Companions asked him why he was weeping, he replied, "It is my humanness."

As Ibrahim's body was being buried, the sun was eclipsed and it grew dark and gloomy. Some people thought this was connected with Ibrahim's death, but the Prophet soon clarified this. "The sun and the moon are two of Allah's signs," he said, "they are not eclipsed because of anyone's birth or death. When you see these signs, make haste to remember Allah in prayer." Although the kafirun used to mock the Prophet Muhammad because he had no sons, and say that he was 'cut off' , Allah made it clear in the following surah that the station of the Prophet Muhammad was far above that of any other man;

In the name of Allah, The Merciful, the Compassionate: Surely We have given you AL Khawthar, so pray to your Lord and offer sacrifice. Surely he who mocks you is the one cut off. (Quran 108:1-3)

Muhammad is not the father of any man among you, but he is the Messenger of Allah and the Seal of the Prophets, and Allah has knowledge of all things. (Quran 33:40)

Maria was honored and respected by the Prophet and his family and Companions. She spent three years of her life with the Prophet, until his death, and died five years later in 16 AH, (may Allah be pleased with her) For the last five years of her life, she remained a recluse and almost never went out except to visit the grave of the Prophet or her son's grave. After her death, Umar ibn al Khattab led the prayer over her and she was buried in al Baqi.